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Rogaine review
All about
Rogaine
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In this
page, you can find the most reliable information about Rogaine.
After reading this Rogaine review, you will be much more informed, and you
will be able to determine if Rogaine good for you or not. Remember:
knowledge is power! Make your own Rogaine review after considering all the
information here. In
this Rogaine review, you can find some sound information about those
issues:
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What is Rogaine?
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Chemical formula
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Who should use Rogaine?
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Who should NOT use Rogaine?
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Rogaine side effects
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What is good with Rogaine?
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What is bad with Rogaine?
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What is Rogaine?
Minoxidil (commercial names
are Rogaine ®
and Regaine ®) is a powerful
direct-acting peripheral vasodilator. It reduces peripheral resistance and
produces a fall in blood pressure.
Thus, it was originally produced as an anti-hypertensive agent. Then, the
scientist discovered that rogaine pills caused increase in body hair as a
side-effect. Following this, numerous studies showed topical Rogaine's
ability to slow down hair loss and promote hair regrowth. Today, Rogaine
is one of two medications which have FDA approval for treatment of
androgenic hair loss (the other one is Propecia).
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Chemical formula
Minoxidil occurs as a white
to off-white, odorless, crystalline solid that is soluble in water, is
readily soluble in propylene glycol or ethanol, and is almost insoluble in
acetone, chloroform or ethyl acetate. The chemical name for minoxidil is
2,4-pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide. Its chemical formula
is below:
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Who should use Rogaine?
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Men: Rogaine is
used to treat male pattern baldness in patients who are experiencing
gradually thinning hair on the top of the head. Rogaine is not meant for
baldness due to some conditions which are known to cause hair loss
(e.g., iron deficiency or medications such as cancer chemotherapy)
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Women: Rogaine
for women works for many women at the earlier stages of hair loss.
Actually, some recent studies have shown that Rogaine works better for
slowing down hair loss in women than it does for men
Who should NOT use Rogaine?
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Anyone who is allergic to minoxidil or
to any of the ingredients of the solution
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Women which are (or may be) pregnant
or nursing
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Anyone who is using other skin
medications on the scalp
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Anyone who has broken, inflamed,
irritated, infected, or severely sunburned scalp
- Who has
heart disease
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Rogaine side effects
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Some users do experience certain problems such as scalp
irritation, itching, and dandruff. However, this can be treated with a good
shampoo.
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Some user reported an increase in
hair shedding at the start of the treatment. It is just temporary,
and treatment should not be stopped. Indeed, this may actually be a signal
that the treatment is working.
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Due to the medication’s alcohol content, some users may develop a contact
rash or irritated skin.
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Because systemic absorption
of topically applied drug may occur, some users may experience dizziness
or a rapid heart beat with excessive doses. However, with normal use these
effects are uncommon.
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A minority of Rogaine users experience
“hypertrichosis” problem. This is
hair growth on the face or other bodily areas. This side effect
appears in about 3-5 % of women who use the 2% solution, and higher among
women using the 5% solution. In this case, the treatment should be stopped.
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What is good with Rogaine?
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It is proven, not bogus: There
are many scientific studies about Rogaine. Most of them show that
Rogaine is good for hair regrowth. Sometimes, the results are so
impressive. Thus, FDA approved its usage for hair loss. Most of the
other medicines and methods out there have no such a proof showing
their efficacy. If you believe science, it is logical to choose a
legitimate medicine, instead of unproven ones which many of them are
just bogus.
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No gender difference: Rogaine is
used for both men (2% or 5%) and women (2% only). Other FDA-approved
medicine Propecia is not approved for use by women.
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Availability: Rogaine is
available without a prescription.
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Usage method: Rogaine is directly
applied to the scalp. You do not have to take it orally. Thus, its
systemic side-effects (to whole body) are minimum to none. So, men
are relieved to know that it works without altering male hormones.
What is bad with Rogaine?
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No guarantee: Rogaine's manufacturer clearly states Rogaine does not
work for everyone and individual results will vary. A clinical test showed about 55% of the men who
used Rogaine obtained some improvement. That means that 45% of the users
will not see satisfactory improvement.
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Not good for forehead: Rogaine
stimulates hair regrowth at the top of the head, not at the forehead. Your
hair loss affects primarily forehead, Rogaine is not good for you.
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Delayed effect: Seeing some hair
improvement, may take time. You need to apply Rogaine 3 or 4 months to see
it starts to work. So, just knowing Rogaine is not good for you may cost
you wasted money and time.
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Continuous treatment: Those who
see some improvement then need to maintain the medication to avoid losing
any hair gained. Its maximum allowed duration of usage is not known.
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Some
scientific information about hair loss and use of Rogaine
Male androgenetic alopecia
Male pattern hair loss is the
most common cause of balding. The pathogenesis involves androgen, and in
particular dihydrotestosterone, binding to androgen receptors in the dermal
papilla of sensitive hair follicles. Hair follicle sensitivity is
genetically determined and shows regional specificity. Androgen stimulation
of scalp dermal papilla cells induces transforming growth factor beta
(TGF-B) and results in cyclical miniaturization of the entire hair follicle.
The resulting hair produced from that follicle is shorter and finer and
provides less complete scalp coverage. In contrast androgen stimulation of
beard dermal papilla cells produces insulin growth factor -2 (IGF-2) and
results in cyclical enlargement of the entire hair follicle. The resulting
hair produced from that follicle is longer and thicker and provides more
complete facial skin coverage. Some degree of androgenetic alopecia is
universal among ageing men, especially bitemporally, however less than half
become bald in the Hippocratic sense. Although scalp hair coverage has
little functional importance, it has cosmetic significance. Baldness changes
the facial appearance of affected men. When that change is perceived as
adverse it has the potential to produce emotional morbidity.
(Excerpted from: Sinclair RD.
JMHG 1, No. 4, pp. 319–327, December 2004)
Androgens and alopecia
Androgens have profound effects
on scalp and body hair in humans. Scalp hair grows constitutively in the
absence of androgens, while body hair growth is dependent on the action of
androgens. Androgenetic alopecia, referred to as male pattern hair loss
(MPHL) in men and female pattern hair loss (FPHL) in women, is due to the
progressive miniaturization of scalp hair. Observations in both eunuchs, who
have low levels of testicular androgens, and males with genetic 5a-reductase
(5aR) deficiency, who have low levels of dihydrotestosterone (DHT),
implicate DHT as a key androgen in the pathogenesis of MPHL in men. The
development of finasteride, a type 2-selective 5aR inhibitor, further
advanced our understanding of the role of DHT in the pathophysiology of
scalp alopecia. Controlled clinical trials with finasteride demonstrated
improvements in scalp hair growth in treated men associated with reductions
in scalp DHT content, and a trend towards reversal of scalp hair
miniaturization was evident by histopathologic evaluation of scalp biopsies.
In contrast to its beneficial effects in men, finasteride did not improve
hair growth in postmenopausal women with FPHL. Histopathological evaluation
of scalp biopsies confirmed that finasteride treatment produced no benefit
on scalp hair in these women. These findings suggest that MPHL and FPHL are
distinct clinical entities, with disparate pathophysiologies. Studies that
elucidate the molecular mechanisms by which androgens regulate hair growth
would provide greater understanding of these differences.
(Excerpted from: Kauman KD.
Molecular and Cellular Endocrinology 198 (2002) 89/95)
5% minoxidil topical foam
versus placebo
In order to assess the efficacy
and safety of a new 5% minoxidil topical formulation in a propylene
glycolefree foam vehicle in men with androgenetic alopecia (AGA), Olsen et
al conducted this study. Their study was a 16-week, double-blind,
placebo-controlled trial of 5% minoxidil topical foam (MTF) in 352 men, 18
to 49 years old. At week 16, 143 subjects continued on an open-label phase
to collect 52 weeks of safety information on 5% MTF. The researchers found
that at week 16 compared with baseline, there was a statistically
significant increase in (1) hair counts in the 5% MTF group versus placebo
(P \.0001) and (2) subjective assessment of improved hair loss condition
(P\.0001) in the 5% MTF group versus placebo. The 5% MTF was well tolerated
over a 52-week period. The researchers believe that 5% MTF is a safe and
effective treatment for men with AGA.
(Excerpted from: Olsen EA et al.
J Am Acad Dermatol 2007;57:767-74.)
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